Autocamtide-2 Related Inhibitory Peptide II - Calbiochem

An AIP (Cat. No. 189480) analog, in which Ala³ and Val¹⁰ are replaced with Lys and Phe respectively. Acts as a highly specific, potent inhibitor of calmodulin-dependent protein kinase II (CaMKII; IC₅₀ = 4.1 nM). Displays ~10-fold greater potency than AIP. Inhibits PKC at higher concentrations (IC₅₀ = 1 µM) and does not affect the activities of CaMK IV and PKA (IC₅₀ >100 µM).

An autocamtide-2 related inhibitory peptide (AIP) analog in which Ala³ and Val¹⁰ have been replaced with Lys and Phe, respectively. Acts as a highly specific, potent inhibitor of calmodulin-dependent protein kinase II (CaMKII) (IC₅₀ = 4.1 nM). Displays ~10-fold greater potency than AIP (Cat. No. 189480). Inhibits PKC at higher concentrations (IC₅₀ = 1 µM), but does not affect the activities of CaMKIV or PKA (IC₅₀ >100 µM).

Cell permeable: no

Primary Target
CAM Kinase-2

Product does not compete with ATP.

Reversible: no

Packaged under inert gas

Supplied as a trifluoroacetate salt.

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

H-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH

Ishida, A., et al. 1998. FEBS Lett.427, 115.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)