189513
Autotaxin Inhibitor IV, HA155
The Autotaxin Inhibitor IV, HA155 controls the biological activity of Autotaxin. This small molecule/inhibitor is primarily used for Cell Structure applications.
别名:
Autotaxin Inhibitor IV, HA155, Atx Inhibitor IV, HA155, ( Z)-4-((4-((3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan-5-yliden)-methyl)phenoxy)methyl)benzeneboronic acid, Atx Inhibitor IV, HA155, (Z)-4-((4-((3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan-5-yliden)-methyl)phenoxy)methyl)benzeneboronic acid
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关于此项目
经验公式（希尔记法）:
C24H19BFNO5S
化学文摘社编号:
分子量:
463.29
UNSPSC Code:
41121800
NACRES:
NA.28
MDL number:
form
powder
InChI key
BRWUZCBSWABPMR-XKZIYDEJSA-N
SMILES string
O=C(/C(S1)=C/C2=CC=C(OCC3=CC=C(B(O)O)C=C3)C=C2)N(CC4=CC=C(F)C=C4)C1=O
assay
≥99% (HPLC)
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
yellow
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A ~5-fold more potent (IC50 = 5.7 nM) para-isomer boronate analog of Autotaxin Inhibitor II, HA130 (Cat. No. 189511) that efficiently blocks thrombin-stimulated lysophosphatidic acid secretion in platelets and in mammalian cells.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Fulkerson, Z., et al. 2011. J. Biol. Chem.286, 34654.
Hausmann, J., et al. 2011. Nat. Struct. Mol. Biol.18, 198.
Albers, H.M.H.G., et al. 2011. J. Med. Chem.54, 4619.
Albers, H.M.H.G., et al. 2010. J. Med. Chem.53, 4958.
Hausmann, J., et al. 2011. Nat. Struct. Mol. Biol.18, 198.
Albers, H.M.H.G., et al. 2011. J. Med. Chem.54, 4619.
Albers, H.M.H.G., et al. 2010. J. Med. Chem.53, 4958.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
wgk
WGK 3
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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