197223
Bcr-abl Inhibitor II - CAS 607702-99-8 - Calbiochem
别名:
Bcr-abl Inhibitor II - CAS 607702-99-8 - Calbiochem, 5-[(4-fluorobenzoyl)amino]-2-[(4-fluorobenzyl)thio]-1,3,4-thiadiazole, Abl Inhibitor II
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 100 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
General description
This product has been discontinued.
A cell-permeable thiadiazole compound that acts as an ATP binding site-targeting inhibitor of Abl and c-Src kinases (Ki = 44 and 354 nM, respectively). Effectively inhibits cellular Bcr-Abl Tyr245 phosphorylation and the clonogenic activity of Bcr-Abl-transformed 32D cells, regardless of their resistance to Imatinib/STI571.
A cell-permeable thiadiazole compound that acts as an ATP binding site-targeting inhibitor of Abl and c-Src kinases (Ki = 44 and 354 nM, respectively). Effectively inhibits cellular Bcr-Abl Tyr245 phosphorylation and the clonogenic activity of Bcr-Abl-transformed 32D cells, regardless of their resistance to Imatinib/STI571.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
Other Notes
Radi, M., et al. 2008. Bioorg. Med. Chem. Lett.18, 1207.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
法规信息
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