200485
Bestatin Methyl Ester - CAS 65322-89-6 - Calbiochem
别名:
Bestatin Methyl Ester - CAS 65322-89-6 - Calbiochem, (-)-N-[(2S, 3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Methyl Ester
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关于此项目
assay
≥97% (TLC)
Quality Level
form
semisolid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
yellowish
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
This product has been discontinued.
A cell-permeable derivative of Bestatin (Cat. No. 200484) that displays slightly stronger inhibition of neutral aminopeptidase than Bestatin but has much weaker activity against basic aminopeptidase. Also augments Fas- or TNF-α-induced apoptosis in solid tumor cell lines.
A cell-permeable derivative of Bestatin (Cat. No. 200484) that displays stronger inhibition of neutral aminopeptidase than Bestatin (IC50 = 31.6 nM). Exhibits weaker activity against basic aminopeptidase (IC50 = 400.1 nM). Also reported to augment Fas- (IC50 = 235.4 nM) or TNF-α-induced apoptosis in solid tumor cell lines.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Neutral amino pepsidase
Neutral amino pepsidase
Product does not compete with ATP.
Reversible: no
Target IC50: 31.6 nM against neutral amino pepsidase
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Unstable in aqueous solution; dilute just prior to use.
Other Notes
Sekine, K., et al. 2001. Int. J. Cancer94, 485.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
10-13 - German Storage Class 10 to 13
法规信息
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