Recombinant, human bone morphogenetic protein-2 (BMP-2) expressed in E. coli and purified by proprietary chromatographic methods. BMP-2 is a homodimeric protein that belongs to the transforming growth factor-β (TGF-β) superfamily. BMP-2 is known to regulate diverse fundamental processes during embryonic development. It also plays an important role in cardiac morphogenesis and is expressed in a variety of tissues such as lung, spleen, brain, liver, prostate, ovary, and small intestine.

Lyophilized from sterile 10 mM sodium citrate, pH 3.5.

Following reconstitution, refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for 2-7 days at 4°C or for up to 6 months at -20°C. Avoid freeze/thaw cycles of solutions.

Reconstitute to ≥100 µg/ml with 20 mM acetic acid containing 0.1% HSA or BSA. Further dilutions can be made in aqueous buffers just prior to use.

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Kuo, P.L., et al. 2006. Biol. Pharm. Bull.29, 119.
Morin, R., et al. 2006. Biomacromolecules7, 131.
Villavicencio, A.T., et al. 2005. J. Neurosurg. Spine3, 436.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)