203661-M
Bruton′s Tyrosine Kinase Inhibitor III - CAS 936563-87-0 - Calbiochem
别名:
Bruton′s Tyrosine Kinase Inhibitor III - CAS 936563-87-0 - Calbiochem, 1-(3-(4-Amino-3-(4-phenyloxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, N-Acryloyl-(3-(4-Amino-3-(4-phenyloxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine
描述
The Bruton′s Tyrosine Kinase Inhibitor III, also referenced under CAS 936563-87-0, controls the biological activity of Bruton′s Tyrosine Kinase.
方案
≥98% (HPLC)
表单
crystalline solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 10 mg/mL (Fresh DMSO is recommended.)
ethanol: 5 mg/mL
储存温度
−20°C
一般描述
A cell-permeable pyrrolopyridinyl-acryloyl compound that acts as a highly potent, selective, and irreversible inhibitor of BTK (IC50 = 720 pM), while affecting Lyn, Lck, and Itk activity only at much higher concentrations (IC50 = 14 nM, 97 nM, and 1.0 µM, respectively). Inhibits BTK-dependent PLC-γ1 phosphorylation and Ca2+ flux in human B cell line Ramos in vitro (IC50 = 14 nM and 40 nM, respectively) and is of excellent efficacy in a murine rheumatoid archritis model in vivo (>95% inhibition at 10 mg/kg/day, p.o.).
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Pan, Z., et al. 2007. ChemMedchem.2, 58.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Regulatory Review (Z)
储存分类代码
10-13 - German Storage Class 10 to 13
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