203697
BPDQ
A cell-permeable, reversible, ATP-competitive, potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC₅₀ = 120 pM).
别名:
BPDQ, 4-[(3-Bromophenyl)amino]-6,7-diaminoquinazoline
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
DMSO: 200 mg/mL
运输
ambient
储存温度
−20°C
一般描述
A cell-permeable, reversible, ATP-competitive, potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 0.12 nM).
生化/生理作用
Cell permeable: yes
Primary Target
EGFR
EGFR
Product competes with ATP.
Reversible: yes
Target IC50: 120 pM against EGFR
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). This product is stable for up to 3 months at -20°C.
其他说明
Rewcastle, G.W., et al. 1996. J. Med. Chem. 39, 918.
Rewcastle, G.W., et al. 1995. J. Med. Chem. 38, 3482.
Rewcastle, G.W., et al. 1995. J. Med. Chem. 38, 3482.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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