203697
BPDQ
A cell-permeable, reversible, ATP-competitive, potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 120 pM).
别名:
BPDQ, 4-[(3-Bromophenyl)amino]-6,7-diaminoquinazoline
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 200 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A cell-permeable, reversible, ATP-competitive, potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 0.12 nM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
EGFR
EGFR
Product competes with ATP.
Reversible: yes
Target IC50: 120 pM against EGFR
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). This product is stable for up to 3 months at -20°C.
Other Notes
Rewcastle, G.W., et al. 1996. J. Med. Chem. 39, 918.
Rewcastle, G.W., et al. 1995. J. Med. Chem. 38, 3482.
Rewcastle, G.W., et al. 1995. J. Med. Chem. 38, 3482.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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