203988
Butyrolactone I
A cell-permeable and highly selective inhibitor of cyclin-dependent protein kinases (Cdks) that inhibits cell cycle progression at the G1/S and G1/M transitions.
别名:
Butyrolactone I
InChI key
FPVUCBMBMUHRDX-XMMPIXPASA-N
InChI
1S/C24H24O7/c1-14(2)4-6-17-12-15(5-11-19(17)26)13-30-23(29)24(3)20(21(27)22(28)31-24)16-7-9-18(25)10-8-16/h4-5,7-12,25-27H,6,13H2,1-3H3/t24-/m1/s1
assay
≥99% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A cell-permeable and highly selective inhibitor of cyclin-dependent protein kinases (Cdks) that inhibits cell cycle progression at the G1/S and G2/M transitions. Inhibits p34cdk1/cyclinB (Cdk1; IC50 = 680 nM). Also selectively inhibits Cdk2 and Cdk5 kinases. Has little effect on casein kinase I, casein kinase II, EGF receptor kinase, MAP kinase, PKA, and PKC. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Also blocks Fas-induced apoptosis in HL-60 cells and shows antitumor effects on human lung cancer cell lines.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
p34cdk1/cyclinB
p34cdk1/cyclinB
Product does not compete with ATP.
Reversible: no
Target IC50: 680 nM against Cdk1
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Furukawa, Y., et al. 1996. J. Biol. Chem. 271, 28469.
Nishio, K., et al. 1996. Anticancer Res. 16, 3387.
Kitagawa, M., et al. 1994. Oncogene 9, 2549.
Kitagawa, M., et al. 1993. Oncogene 8, 2425.
Nishio, K., et al. 1996. Anticancer Res. 16, 3387.
Kitagawa, M., et al. 1994. Oncogene 9, 2549.
Kitagawa, M., et al. 1993. Oncogene 8, 2425.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Alessia Oppezzo et al.
Cell & bioscience, 13(1), 115-115 (2023-06-25)
Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) niche, which includes bone-forming and bone-resorbing cells, i.e., osteoblasts (OBs) and osteoclasts (OCs). OBs originate from mesenchymal progenitors, while OCs are derived from HSCs. Self-renewal, proliferation and differentiation of HSCs
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