产品名称
氯化卡咪唑, A cell-permeable calmodulin antagonist.
InChI
1S/C31H24Cl6N2O.Cl/c32-23-6-1-20(2-7-23)31(21-3-8-24(33)9-4-21)39-14-13-38(19-39)17-30(27-12-11-26(35)16-29(27)37)40-18-22-5-10-25(34)15-28(22)36;/h1-16,30-31H,17-19H2;
InChI key
LBFGPQFQXRJXDI-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 10 mg/mL
ethanol: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
主要靶标
脑钙调蛋白依赖性磷酸二酯酶
脑钙调蛋白依赖性磷酸二酯酶
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
靶标IC50：10 nM，针对脑钙调蛋白依赖性磷酸二酯酶
Disclaimer
在水溶液中容易粘附在玻璃上。
毒性：标准处理（A）
General description
注意：在水溶液中容易粘附在玻璃上。
细胞可渗透的钙调蛋白拮抗剂。sepazonium的类似物作为脑Ca2+-钙调蛋白依赖性磷酸二酯酶（IC50=10 nM）的抑制剂，其效力至少是三氟拉嗪（目录编号642150）的150倍。抑制电压门控Ca2+通道并刺激神经母细胞瘤细胞释放一氧化氮。还充当红细胞中钙依赖性Ca2+-ATPase的强抑制剂。已知可延长体内心脏不应期。
细胞可渗透的钙调蛋白拮抗剂。作为脑钙调蛋白依赖性磷酸二酯酶（IC50=10 nM）的抑制剂，其效力至少是三氟拉嗪（目录编号642150）的150倍。电压门控Ca2+通道的抑制剂。刺激神经母细胞瘤细胞释放一氧化氮。还充当骨骼肌肌浆网Ca2+-ATPase（Ki=60 nM）的强非竞争性抑制剂。已知可延长体内心脏不应期。
Other Notes
Hu, J., and El-Fakahany, E.E.1993.NeuroReport.4, 198.
Nakazawa, K., et al. 1993.Br. J. Pharmacol.109, 137.
Yuasa, T., and Muto, S. 1992.Arch.Biochem.Biophys.296, 175.
Ichikawa, M., et al. 1991.J. Membrane Biol.120, 211.
Silver, P.J., et al. 1989.Cardiovasc.Drug Ther.3, 675.
Anderson, K.W., et al. 1984.J. Biol. Chem.259, 11487.
Gietzen, L., et al. 1982.Biochem.J. 207, 541.
Van Belle, H. 1981.Cell Calcium2, 483.
Levin, R.N., and Weiss, B. 1979.J. Pharmacol.Exp.Therap.208, 454.
Nakazawa, K., et al. 1993.Br. J. Pharmacol.109, 137.
Yuasa, T., and Muto, S. 1992.Arch.Biochem.Biophys.296, 175.
Ichikawa, M., et al. 1991.J. Membrane Biol.120, 211.
Silver, P.J., et al. 1989.Cardiovasc.Drug Ther.3, 675.
Anderson, K.W., et al. 1984.J. Biol. Chem.259, 11487.
Gietzen, L., et al. 1982.Biochem.J. 207, 541.
Van Belle, H. 1981.Cell Calcium2, 483.
Levin, R.N., and Weiss, B. 1979.J. Pharmacol.Exp.Therap.208, 454.
Preparation Note
复溶后，等分并冷冻长期保存（-20°C），或冷藏（4°C）短期保存。DMSO储备溶液在-20°C下可稳定保存2个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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