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Merck
CN

208711

Ca2+/Calmodulin Kinase II Inhibitor 281-309

The Ca2+/Calmodulin Kinase II Inhibitor 281-309 controls the biological activity of Ca2+/Calmodulin Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

别名:

Ca2+/Calmodulin Kinase II Inhibitor 281-309, CaM Kinase II Inhibitor 281-309, MHRQETVDCLKKFNARRKLKGAILTTMLA-OH

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关于此项目

经验公式（希尔记法）:
C146H254N46O39S3
分子量:
3374.06
UNSPSC Code:
12352200

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assay

≥97% (HPLC)

form

lyophilized solid

potency

80 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

solubility

water: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

General description

A synthetic peptide containing the calmodulin binding site (290-309) and the autophosphorylation site (Thr286) of CaM kinase II. Can be phosphorylated at Thr286 by PKC. Useful as a calmodulin binding peptide. Inhibits CaM kinase II by blocking Ca2+/calmodulin activation (IC50 = 80 nM) and enzyme-active site (IC50 = 2 µM).
A synthetic peptide that contains the CaM-binding, inhibitory, and autophosphorylation domains of CaM kinase II. Can be phosphorylated at Thr286 by PKC. Useful as a calmodulin binding peptide. Inhibits CaM kinase II (IC50 = 80 nM) by blocking Ca2+/calmodulin activation and enzyme active site (IC50 = 2 µM).

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: no

Packaging

Yes

Other Notes

H-Met-His-Arg-Gln-Glu-Thr-Val-Asp-Cys-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
Waxham, M.N., et al. 1993. Biochemistry32, 2923.
Waxham, M.N., et al. 1993. Brain Res. 609, 1.
Fukunaga, K., et al. 1990. J. Neurochem.54, 103.
Colbran, R.J., et al. 1989. J. Biol. Chem. 264, 4800.
Colbran, R.J., et al. 1988. J. Biol. Chem.263, 18145.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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