215902-M
Carbonic Anhydrase IX Inhibitor III, Methazolamide
The Carbonic Anhydrase IX Inhibitor III, Methazolamide, also referenced under CAS 554-57-4, controls the biological activity of Carbonic Anhydrase IX.
别名:
Carbonic Anhydrase IX Inhibitor III, Methazolamide, N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide, Carbonic Anhydrase Inhibitor, Methazolamide, CAIX Inhibitor III
方案
≥99% (HPLC)
表单
powder
效能
20 nM Ki
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 50 mg/mL
储存温度
2-8°C
InChI
1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)
InChI key
FLOSMHQXBMRNHR-UHFFFAOYSA-N
一般描述
A cell-permeable thiadiazolylsulfonamide derivative that acts as a carbonic anhydrase (CA) inhibitor (Ki = 20 nM) with anti-glaucoma, anti-diabetic, and potential anti-neoplastic activity. May induce death in hypoxic tumor cells by inhibiting tumor-associated CAIX in maintaining an acidic tumor microenvironment, and blocking CAIX-dependent resistance to chemotherapy in these tumors. Shown to enhance insulin sensitivity and reduce HbA1c levels in diabetic rodent models in a dose-dependent manner. Shown to reduce oxygen and glucose-deprived cell death in primary cerebrocortical neurons by diminishing the release of cytochrome c and dissipating the mitochondrial membrane potential gradient.
生化/生理作用
Primary Target
carbonic anhydrase
carbonic anhydrase
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Maren, T., et al. 1977. Invest Ophthalmol Vis Sci.16, 730.
Chegwidden, W. R. and Spencer, I. M. 1995. Inflammopharmacology.3, 231.
Wang, X., et al. 2009. Stroke.40, 1877.
Konstantopoulos, N., et al. 2012. Diabetes.
Chegwidden, W. R. and Spencer, I. M. 1995. Inflammopharmacology.3, 231.
Wang, X., et al. 2009. Stroke.40, 1877.
Konstantopoulos, N., et al. 2012. Diabetes.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
法规信息
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