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Merck
CN

215921

Sigma-Aldrich

Chlorpromazine hydrochloride

≥99% (HPLC), calmodulin-dependent phosphodiesterase inhibitor, crystalline solid

别名:

Chlorpromazine, Hydrochloride

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关于此项目

经验公式（希尔记法）:
C17H19ClN2S · xHCl
CAS Number:
69-09-0
分子量:
318.86 (free base basis)
MDL编号:
MFCD00012654
UNSPSC代码:
12352200
NACRES:
NA.77

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Product Name

Chlorpromazine, Hydrochloride, Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM).

质量水平

100

描述

Merck USA index - 14, 2185

方案

≥99% (HPLC)

表单

crystalline solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)

颜色

off-white

溶解性

methanol: 10 mg/mL
water: 50 mg/mL

痕量阴离子

sulfate (SO42-): ≤0.05%

痕量阳离子

Fe: ≤0.001%
heavy metals: ≤0.002%

运输

ambient

储存温度

10-30°C

SMILES字符串

S1c2c(cc(cc2)Cl)N(c3c1cccc3)CCC[N+H](C)C.[Cl-]

InChI

1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

InChI key

FBSMERQALIEGJT-UHFFFAOYSA-N

相关类别

一般描述

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC50 = 17 µM). Acts as a peripheral vasodilator. An inhibitor of TNFα production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC50<10 µM), and PLA2.

生化/生理作用

Primary Target
Calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase
Product does not compete with ATP.
Target IC50: 17 µM inhibiting calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase

制备说明

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C and for up to 1 week at 4°C.

其他说明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Lee, M.S., et al. 2007. Cancer Res.67, 11359.
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Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393.
Lindahl, M., and Tagesson, C. 1993. Inflammation17, 573.
Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280.
Yamamoto, H. 1993. Toxicol. Lett. 66, 73.
Vadas, P., et al. 1986. Agents Actions19, 194.
Marshak, P.R., et al. 1985. Biochemistry24, 144.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Toxic (F)

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301,H330

危险分类

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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David W Sanders et al.
eLife, 10 (2021-04-24)
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