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Merck
CN

215921

Chlorpromazine hydrochloride

≥99% (HPLC), calmodulin-dependent phosphodiesterase inhibitor, crystalline solid

别名:

Chlorpromazine, Hydrochloride

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关于此项目

经验公式（希尔记法）:
C17H19ClN2S · xHCl
化学文摘社编号:
69-09-0
分子量:
318.86 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00012654

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产品名称

Chlorpromazine, Hydrochloride, Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC50 = 17 µM).

SMILES string

S1c2c(cc(cc2)Cl)N(c3c1cccc3)CCC[N+H](C)C.[Cl-]

InChI

1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

InChI key

FBSMERQALIEGJT-UHFFFAOYSA-N

description

Merck USA index - 14, 2185

assay

≥99% (HPLC)

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

color

off-white

solubility

methanol: 10 mg/mL, water: 50 mg/mL

anion traces

sulfate (SO42-): ≤0.05%

cation traces

Fe: ≤0.001%, heavy metals: ≤0.002%

shipped in

ambient

storage temp.

10-30°C

Quality Level

100

相关类别

General description

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC50 = 17 µM). Acts as a peripheral vasodilator. An inhibitor of TNFα production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC50<10 µM), and PLA2.

Biochem/physiol Actions

Primary Target
Calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase
Product does not compete with ATP.
Target IC50: 17 µM inhibiting calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase

Preparation Note

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C and for up to 1 week at 4°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Lee, M.S., et al. 2007. Cancer Res.67, 11359.
Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378.
Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393.
Lindahl, M., and Tagesson, C. 1993. Inflammation17, 573.
Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280.
Yamamoto, H. 1993. Toxicol. Lett. 66, 73.
Vadas, P., et al. 1986. Agents Actions19, 194.
Marshak, P.R., et al. 1985. Biochemistry24, 144.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H330

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

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David W Sanders et al.
eLife, 10 (2021-04-24)
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