217720
Cdk1/5 Inhibitor
The Cdk1/5 Inhibitor, also referenced under CAS 40254-90-8, controls the biological activity of Cdk1/5. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Cdk1/5 Inhibitor, 3-Amino-1H-pyrazolo[3,4-b]quinoxaline
InChI key
DWHVZCLBMTZRQM-UHFFFAOYSA-N
InChI
1S/C9H7N5/c10-8-7-9(14-13-8)12-6-4-2-1-3-5(6)11-7/h1-4H,(H3,10,12,13,14)
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
red
solubility
DMSO: 5 mg/mL
shipped in
ambient
Quality Level
General description
A 3-amino substituted pyrazoloquinoxaline compound that acts as a selective inhibitor of cyclin-dependent kinases 1 and 5 (Cdks; IC50 = 0.6 µM and 0.4 µM for Cdk1/cyclin B and Cdk5/p25, respectively). Also shown to inhibit GSK-3β with (IC50 = 1 µM). Does not inhibit Cdc25 phosphatase activity (IC50 >10 µM).
A selective inhibitor of cyclin-dependent kinases 1 and 5 (Cdk1/Cdk5) (IC50 = 600 nM for Cdk1/cyclin B and 400 nM for Cdk5/p25). Also shown to inhibit glycogen synthase kinase-3β (GSK-3β) (IC50 = 1 µM). Does not inhibit Cdc25 phosphatase activity (IC50 >10 µM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
Cdk1/cyclin B, Cdk5/p25
Cdk1/cyclin B, Cdk5/p25
Product does not compete with ATP.
Reversible: no
Target IC50: 0.6 µM and 0.4 µM for Cdk1/cyclin B and Cdk5/p25, respectively
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Ortega, M.A., et al. 2002. Bioorg. Med. Chem.10, 2177.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
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