218718
Casein Kinase II Inhibitor VI, TMCB
The Casein Kinase II Inhibitor VI, TMCB, also referenced under CAS 905105-89-7, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Casein Kinase II Inhibitor VI, TMCB, ERK8 Inhibitor I, 4,5,6,7- Tetrabromo-2-di methylamino-1- carboxymethyl- benzimidazole, K66, Erk Inhibitor VI, ERK8 Inhibitor I, 4,5,6,7-Tetrabromo-2-dimethylamino-1-carboxymethyl-benzimidazole, K66, Erk Inhibitor VI
质量水平
方案
≥97% (HPLC)
表单
powder
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 13.3 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C11H9Br4N3O2/c1-17(2)11-16-9-7(14)5(12)6(13)8(15)10(9)18(11)3-4(19)20/h3H2,1-2H3,(H,19,20)
InChI key
PHAOTASRLQMKBE-UHFFFAOYSA-N
一般描述
A cell-permeable tertabromobenzimidazolo TBB (Cat. Nos. 218699 and 218708 ) analog that acts as a highly selective (IC50 >10 µM against 71 other kinases) ATP-competitive inhibitor against CK2 (IC50 = 500 nM; Ki = 250 nM) and ERK8 (IC50 = 500 nM). K66 is reported to be more selective than either TBB or DMAT and selective CK2 inhibition by K66 is shown to be cytotoxic to non-ERK8-expressing Jurkat cells.
包装
Packaged under inert gas
其他说明
Pagano, M.A., et al. 2008. Biochem. J.415, 353.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Irritant (B)
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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