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Merck
CN

219489

Ceramide Kinase Inhibitor, K1

别名:

Ceramide Kinase Inhibitor, K1, F-12509A Cyclic Product K1

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关于此项目

经验公式（希尔记法）:
C21H28O4
化学文摘社编号:
1258005-85-4
分子量:
344.44
UNSPSC Code:
12352200

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assay

≥95% (mixture of enantiomers, NMR)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

ethanol: 20 mg/mL

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

General description

This product has been discontinued.



A cell-permeable tetracyclic quinone compound that acts as a specific, reversible, and non-competitive inhibitor of CerK (ceramide kinase) activity (IC50 = ~5 µM) with little effect against SPHK1/2 or DGKγ (IC50 >100 µM). Shown to reduce cellular C1P (ceramide-1-phosphate) synthesis by 40% at ≥ 20 µM in a rat basophilic leukemia cell line RBL-2H3 and block CerK-mediated degranulation in both RBL-2H3 and murine BMMC (bone marrow-derived mast cells) in a dose-dependent manner. Exhibits no cytotoxic effect against RBL-2H3 even at concentrations as high as 100 µM.

A cell-permeable tetracyclic quinone compound that acts as a specific, reversible, and non-competitive inhibitor of CerK (ceramide kinase) activity (IC50 ~5 µM) with little effect against SPHK1/2 or DGKγ (IC50 >100 µM). Shown to reduce cellular C1P (ceramide-1-phosphate) synthesis by 40% at ≥20 µM in a rat basophilic leukemia cell line RBL-2H3 and block CerK-mediated degranulation in both RBL-2H3 and murine BMMC (bone marrow-derived mast cells) in a dose-dependent manner. Exhibits no cytotoxic effect against RBL-2H3 even at concentrations as high as 100 µM.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Kim, J.W., et al. 2007. Biochim. Biophys. Acta1771, 1262.
Kumada, H., et al. 2007. Biosci. Biotechnol. Biochem.71, 2581
Kim, J.W., et al. 2005. Biochim. Biophys. Acta1738, 82.

Legal Information

Sold for research purposes only.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

10-13 - German Storage Class 10 to 13

法规信息

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