Name: Ceramide Kinase Inhibitor, K1
Brand: MM

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About This Item

经验公式（希尔记法）:

C₂₁H₂₈O₄

CAS Number:

1258005-85-4

分子量:

344.44

UNSPSC代码:

12352200

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方案

≥95% (mixture of enantiomers, NMR)

质量水平

100

表单

powder

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze
protect from light

颜色

yellow

溶解性

ethanol: 20 mg/mL

运输

wet ice

储存温度

−20°C

一般描述

This product has been discontinued.

A cell-permeable tetracyclic quinone compound that acts as a specific, reversible, and non-competitive inhibitor of CerK (ceramide kinase) activity (IC₅₀ = ~5 µM) with little effect against SPHK1/2 or DGKγ (IC₅₀ >100 µM). Shown to reduce cellular C1P (ceramide-1-phosphate) synthesis by 40% at ≥ 20 µM in a rat basophilic leukemia cell line RBL-2H3 and block CerK-mediated degranulation in both RBL-2H3 and murine BMMC (bone marrow-derived mast cells) in a dose-dependent manner. Exhibits no cytotoxic effect against RBL-2H3 even at concentrations as high as 100 µM.

A cell-permeable tetracyclic quinone compound that acts as a specific, reversible, and non-competitive inhibitor of CerK (ceramide kinase) activity (IC₅₀ ~5 µM) with little effect against SPHK1/2 or DGKγ (IC₅₀ >100 µM). Shown to reduce cellular C1P (ceramide-1-phosphate) synthesis by 40% at ≥20 µM in a rat basophilic leukemia cell line RBL-2H3 and block CerK-mediated degranulation in both RBL-2H3 and murine BMMC (bone marrow-derived mast cells) in a dose-dependent manner. Exhibits no cytotoxic effect against RBL-2H3 even at concentrations as high as 100 µM.

包装

Packaged under inert gas

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Kim, J.W., et al. 2007. Biochim. Biophys. Acta1771, 1262.
Kumada, H., et al. 2007. Biosci. Biotechnol. Biochem.71, 2581
Kim, J.W., et al. 2005. Biochim. Biophys. Acta1738, 82.

法律信息

Sold for research purposes only.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Standard Handling (A)

储存分类代码

10-13 - German Storage Class 10 to 13

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