219503
Cdk4 Inhibitor V
The Cdk4 Inhibitor V, also referenced under CAS 943746-57-4, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Cdk4 Inhibitor V, 4-(((4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino)-methylene)-6-iodo-4H-isoquinoline-1,3-dione
产品名称
Cdk4 Inhibitor V, The Cdk4 Inhibitor V, also referenced under CAS 943746-57-4, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
SMILES string
O=C(/C1=C\NCC2=CC(O)=C(OCCC)C=N2)NC(C3=C1C=C(I)C=C3)=O
assay
≥98% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
caramel
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Disclaimer
Toxicity: Regulatory Review (Z)
General description
A cell-permeable and metabolically stable (t1/2 >30 min at 37 °C in the presence of rat liver microsomes, NADPH, and UDPGA) pyridinylmethylamino-isoquinoline dione that acts as a potent, ATP-binding site-targeting inhibitor against Cdk4/D1 kinase activity (IC50 = 30 nM in cell-free Rb c-terminal fragment phosphorylation assays) and an effective antiproliferative agent against HCT116 colorectal and MCF-7 breast cancer cultures (IC50 = 0.73 and 0.88 µM, respectively), while affecting Cdk2/E and Cdk1/B kinase activities only at much higher concentrations (IC50 = 1.6 and 25.3 µM, respectively).
Other Notes
Tsou, H.R., et al. 2009. J. Med. Chem.52, 2289.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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