219505
CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem
别名:
CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem, 5-Ethyl-4-(4ʹ-methoxyphenyl)-thiazolyl-2-amine, CBFα-CBFβ Inhibitor I, CBFβ-Runx1 Inhibitor I
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关于此项目
assay
≥97% (HPLC)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
tan
solubility
DMSO: 20 mg/mL, ethanol: 20 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
This product has been discontinued.
A cell-permeable thiazolyl compound that binds to CBFβ (core binding factor β) and allosterically disrupts CBFα/Runx1 binding to CBFβ both in cell-free binding studies (IC50 of ~3.5 µM by FRET and ELISA) and in HEK293 cells (IC50 of ~ 100 µM by FACS/FRET). Cellular studies indicate a good correlation between the inhibitor′s antiproliferative activity and the Runx1 expression level in the target cells.
A cell-permeable thiazolyl compound that binds to CBFβ (core binding factor β) and allosterically disrupts CBFα/Runx1 binding to CBFβ both in cell-free binding studies (IC50 of ~3.5 µM by FRET and ELISA) and in HEK293 cells (IC50 of ~100 µM by FACS/FRET). Cellular studies indicate a good correlation between the inhibitor′s antiproliferative activity and the Runx1 expression level in the target cells.
Other Notes
Gorczynski, M.J., et al. 2007. Chem. Biol.14, 1186.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
10-13 - German Storage Class 10 to 13
法规信息
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