234109-M
Colcemid
≥98% (HPLC), Microtuble polymeration inhibitor, crystalline powder
别名:
Colcemid, Demecolcine
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C21H25NO5
化学文摘社编号:
分子量:
371.43
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.25
产品名称
Colcemid, Cell synchronization agent.
SMILES string
N(C1CCc2c(c(c(c(c2)OC)OC)OC)C3=CC=C(C(=O)C=C31)OC)C
InChI
1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3
InChI key
NNJPGOLRFBJNIW-UHFFFAOYSA-N
description
Merck USA index - 14, 2887
assay
≥98% (HPLC)
form
crystalline powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
chloroform: 10 mg/mL
ethanol: soluble
storage temp.
10-30°C
Quality Level
Biochem/physiol Actions
Primary Target
Depolymerizes microtubules and limits microtubule formation.
Depolymerizes microtubules and limits microtubule formation.
Disclaimer
Toxicity: Toxic & Carcinogenic / Teratogenic (G)
General description
Cell synchronization agent. Induces apoptosis by blocking mitosis in HeLa S3 cells. Depolymerizes microtubules and limits microtubule formation. Appropriate dilutions inactivate the spindle fiber mechanism during metaphase, systematically immobilizing chromosomes at the metaphase plate.
Other Notes
Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
Kanda, R., et al. 1994. J. Radiat. Res. 35, 41.
Sherwood, S.W., et al. 1994. Exp. Cell Res. 215, 373.
Nishiyama, I., and Fuji, T. 1992. Exp. Cell Res.198, 214.
Spoerri, P.E., and Roisen, F.J. 1992. J. Neurosci. Res.31, 494.
Kanda, R., et al. 1994. J. Radiat. Res. 35, 41.
Sherwood, S.W., et al. 1994. Exp. Cell Res. 215, 373.
Nishiyama, I., and Fuji, T. 1992. Exp. Cell Res.198, 214.
Spoerri, P.E., and Roisen, F.J. 1992. J. Neurosci. Res.31, 494.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 6 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
法规信息
新产品
此项目有
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持