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Merck
CN

234491

Sigma-Aldrich

PD 153035

InSolution, ≥97%, potent and specific inhibitor of the tyrosine kinase activity of EGFR

别名:

InSolution PD 153035

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关于此项目

经验公式（希尔记法）:
C16H14BrN3O2
分子量:
360.21
UNSPSC代码:
12352200

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质量水平

100

方案

≥97% (HPLC)

表单

liquid

效能

25 pM IC50

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)
protect from light

运输

wet ice

储存温度

2-8°C

一般描述

An extremely potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.

生化/生理作用

Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target Ki: 6 pM against the tyrosine kinase activity of the epidermal growth factor receptor (EGFR)

包装

Packaged under inert gas

外形

A 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234490) in DMSO.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Irritant (B)

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

188.6 °F - closed cup - (Dimethylsulfoxide)

闪点(°C)

87 °C - closed cup - (Dimethylsulfoxide)

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Thibaut Renard et al.
Scientific reports, 12(1), 21228-21228 (2022-12-10)
The reproductive division of labour is a hallmark of eusocial Hymenoptera. Females are either reproductive queens or non-reproductive workers. In ants, workers often display further task specialisation that is associated with variation in size and/or morphology. Because female polyphenism is
Carolina Franco Nitta et al.
eLife, 10 (2021-11-26)
Crosstalk between different receptor tyrosine kinases (RTKs) is thought to drive oncogenic signaling and allow therapeutic escape. EGFR and RON are two such RTKs from different subfamilies, which engage in crosstalk through unknown mechanisms. We combined high-resolution imaging with biochemical

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