质量水平
方案
≥97% (HPLC)
表单
liquid
效能
25 pM IC50
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
运输
wet ice
储存温度
2-8°C
一般描述
An extremely potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.
生化/生理作用
Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target Ki: 6 pM against the tyrosine kinase activity of the epidermal growth factor receptor (EGFR)
包装
Packaged under inert gas
外形
A 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234490) in DMSO.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Irritant (B)
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
闪点(°C)
87 °C - closed cup - (Dimethylsulfoxide)
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