产品名称
PD 153035, InSolution, ≥97%, potent and specific inhibitor of the tyrosine kinase activity of EGFR
assay
≥97% (HPLC)
form
liquid
potency
25 pM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
shipped in
wet ice
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Target Ki: 6 pM against the tyrosine kinase activity of the epidermal growth factor receptor (EGFR)
Product competes with ATP.
Reversible: yes
Cell permeable: yes
Disclaimer
Toxicity: Irritant (B)
General description
An extremely potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.
Packaging
Packaged under inert gas
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Physical form
A 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234490 ) in DMSO.
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
DNA methylation and expression of the egfr gene are associated with worker size in monomorphic ants.
Thibaut Renard et al.
Scientific reports, 12(1), 21228-21228 (2022-12-10)
The reproductive division of labour is a hallmark of eusocial Hymenoptera. Females are either reproductive queens or non-reproductive workers. In ants, workers often display further task specialisation that is associated with variation in size and/or morphology. Because female polyphenism is
Carolina Franco Nitta et al.
eLife, 10 (2021-11-26)
Crosstalk between different receptor tyrosine kinases (RTKs) is thought to drive oncogenic signaling and allow therapeutic escape. EGFR and RON are two such RTKs from different subfamilies, which engage in crosstalk through unknown mechanisms. We combined high-resolution imaging with biochemical
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