236011
COX-2 Inhibitor I
The COX-2 Inhibitor I, also referenced under CAS 416901-58-1, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications.
别名:
COX-2 Inhibitor I, LM-1685, Methyl [5-methylsulfonyl-1-(4-chlorobenzyl)-1H-2-indolyl]carboxylate
登录 查看组织和合同定价。
选择尺寸
关于此项目
Assay:
≥97% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
methanol: 1 mg/mL, DMSO: 100 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A cell-permeable potent and selective inhibitor of COX-2 from human monocytes (IC50 = 650 nM) and in whole blood (IC50 = 4.3 µM). Displays only very weak activity against COX-1 from human platelets (IC50 >10 µM) and in whole blood (IC50 >100 µM).
A cell-permeable potent, selective inhibitor of cyclooxygenase-2 (COX-2) (IC50 = 650 nM, human monocytes COX-2). Shown to specifically inhibit COX-2 in human whole blood (IC50 = 4.3 µM). Displays only weak inhibitory activity against COX-1 from human platelets (19% inhibition at 10 µM) and in whole blood (25% inhibition at 100 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
COX-2 from human monocytes
COX-2 from human monocytes
Product does not compete with ATP.
Reversible: no
Target IC50: 650 nM against COX-2 from human monocytes; 4.3 µM against COX-2 in whole blood
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Palomer, A., et al. 2002. J. Med. Chem.45, 1402.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Cheol Ho Heo et al.
Journal of functional biomaterials, 14(4) (2023-04-27)
Cyclooxygenase-2 (COX-2) is a biomolecule known to be overexpressed in inflammation. Therefore, it has been considered a diagnostically useful marker in numerous studies. In this study, we attempted to assess the correlation between COX-2 expression and the severity of intervertebral
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持