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Merck
CN

236013

Millipore

COX-2 Inhibitor III - CAS 1177728-24-3 - Calbiochem

别名:

COX-2 Inhibitor III - CAS 1177728-24-3 - Calbiochem, N-(5-Acetyl-2-piperidinophenyl)-Nʹ-(2,5-dichlorophenyl)thiourea, BTB 02472

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关于此项目

经验公式（希尔记法）:
C20H21Cl2N3OS
化学文摘社编号:
1177728-24-3
分子量:
422.37
UNSPSC代码:
12352200

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方案

≥95% (HPLC)

质量水平

100

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

off-white

溶解性

ethanol: 0.5 mg/mL
DMSO: 200 mg/mL

运输

ambient

储存温度

2-8°C

一般描述

This product has been discontinued.



A thiourea compound that acts as an active-site-targeting COX-2 inhibitor. Exhibits better selectivity than Nimesulide and Celecoxib (% inhibition of COX-1 and COX-2 at 10.0 µM inhibitor concentration = 5.1 and 26.36 with BTB 02472; 9.87 and 19.94 with Nimesulide; 12.35 and 40.37 with Celecoxib).

A thiourea compound that acts as an active-site-targeting COX-2 inhibitor. Exhibits better selectivity than Nimesulide and Celecoxib (% inhibition of COX-1 and COX-2 at 10.0 µM inhibitor concentration = 5.1 and 26.36 with BTB 02472; 9.87 and 19.94 with Nimesulide; 12.35 and 40.37 with Celecoxib).

生化/生理作用

Cell permeable: no
Primary Target
COX-2
Product does not compete with ATP.
Reversible: no
Target IC50: at 10.0 µM, % inhibition of COX-1 and COX-2 = 5.1 and 26.36

包装

Packaged under inert gas

制备说明

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Michaux, C., et al. 2006. Eur. J. Med. Chem.41, 1446.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Standard Handling (A)

储存分类代码

10-13 - German Storage Class 10 to 13

法规信息

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