236013
COX-2 Inhibitor III - CAS 1177728-24-3 - Calbiochem
别名:
COX-2 Inhibitor III - CAS 1177728-24-3 - Calbiochem, N-(5-Acetyl-2-piperidinophenyl)-Nʹ-(2,5-dichlorophenyl)thiourea, BTB 02472
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
ethanol: 0.5 mg/mL, DMSO: 200 mg/mL
shipped in
ambient
Quality Level
General description
This product has been discontinued.
A thiourea compound that acts as an active-site-targeting COX-2 inhibitor. Exhibits better selectivity than Nimesulide and Celecoxib (% inhibition of COX-1 and COX-2 at 10.0 µM inhibitor concentration = 5.1 and 26.36 with BTB 02472; 9.87 and 19.94 with Nimesulide; 12.35 and 40.37 with Celecoxib).
A thiourea compound that acts as an active-site-targeting COX-2 inhibitor. Exhibits better selectivity than Nimesulide and Celecoxib (% inhibition of COX-1 and COX-2 at 10.0 µM inhibitor concentration = 5.1 and 26.36 with BTB 02472; 9.87 and 19.94 with Nimesulide; 12.35 and 40.37 with Celecoxib).
Biochem/physiol Actions
Cell permeable: no
Primary Target
COX-2
COX-2
Product does not compete with ATP.
Reversible: no
Target IC50: at 10.0 µM, % inhibition of COX-1 and COX-2 = 5.1 and 26.36
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Michaux, C., et al. 2006. Eur. J. Med. Chem.41, 1446.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
10-13 - German Storage Class 10 to 13
法规信息
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