239763-M
环己酰亚胺，大包装
Cycloheximide, CAS 66-81-9, is an antifungal antibiotic that inhibits protein synthesis in eukaryotes but not prokaryotes.
别名:
环己酰亚胺，大包装
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关于此项目
经验公式（希尔记法）:
C15H23NO4
化学文摘社编号:
分子量:
281.35
UNSPSC Code:
12352111
NACRES:
NA.77
MDL number:
产品名称
环己酰亚胺，大包装, Cycloheximide, CAS 66-81-9, is an antifungal antibiotic that inhibits protein synthesis in eukaryotes but not prokaryotes.
SMILES string
N1C(=O)CC(CC1=O)C[C@@H](O)[C@@H]2C[C@H](C[C@@H](C2=O)C)C
InChI
1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
InChI key
YPHMISFOHDHNIV-FSZOTQKASA-N
assay
≥90% (by assay)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white to brown
storage temp.
room temp
Quality Level
Disclaimer
毒性：高毒性 & 致癌性/致畸性（I）
General description
一种抗真菌抗生素，可抑制真核生物中的蛋白质合成，但不抑制原核生物中的蛋白质合成。直接与易位酶相互作用，干扰易位步骤。抑制真核生物中无细胞蛋白的合成。 竞争性抑制hFKBP12（Ki = 3.4 µM）。在HL-60细胞、T细胞杂交瘤、Burkitt′s淋巴瘤细胞和包括啮齿动物巨噬细胞在内的多种其他细胞类型中引发凋亡。诱导巨噬细胞中的DNA片段化，但抑制用毒胡萝卜素，甲基泼尼松龙和离子霉素处理的大鼠胸腺细胞中的DNA裂解。在碱性溶液中迅速被破坏。
Other Notes
Christner, C., et al. 1999.J. Med. Chem.42, 3615.
Lu, Q. and Mellgreen,R.L.1996.Arch.Biochem.Biophys.334, 175.
Chow, S.C., et al. 1995.Exp.Cell Res.216, 149.
Waring, P. 1990.J. Biol. Chem.265, 14476.
Obrig, T.G., et al. 1971.J. Biol. Chem.246, 174.
Pestka, S. 1971.Annu.Rev. Microbiol.25, 487.
Lu, Q. and Mellgreen,R.L.1996.Arch.Biochem.Biophys.334, 175.
Chow, S.C., et al. 1995.Exp.Cell Res.216, 149.
Waring, P. 1990.J. Biol. Chem.265, 14476.
Obrig, T.G., et al. 1971.J. Biol. Chem.246, 174.
Pestka, S. 1971.Annu.Rev. Microbiol.25, 487.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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