239764
环己酰亚胺，高纯度
Antifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes.
别名:
环己酰亚胺，高纯度
InChI
1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
InChI key
YPHMISFOHDHNIV-FSZOTQKASA-N
assay
≥98% (HPLC)
form
solid
potency
3.4 μM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
chloroform: soluble, ethanol: soluble, methanol: soluble
shipped in
ambient
storage temp.
10-30°C
Quality Level
General description
一种抗真菌抗生素，在100 µg/ml时对几种病原菌没有抑制作用。抑制真核生物中的蛋白质合成，但不抑制原核生物中的蛋白质合成。直接与易位酶相互作用，干扰易位步骤。抑制真核生物中无细胞蛋白的合成。竞争性抑制hFkBP12（Ki = 3.4 µM）。在HL-60细胞、T细胞杂交瘤、Burkitt′s淋巴瘤细胞和包括啮齿动物巨噬细胞在内的多种其他细胞类型中引发凋亡。抑制用毒胡萝卜素，甲基泼尼松龙和离子霉素处理的大鼠胸腺细胞中的DNA裂解。在碱性溶液中迅速被破坏。
Biochem/physiol Actions
主要靶标
hFKBP12
hFKBP12
Preparation Note
复溶后，等分并冷冻长期保存（-20°C），或冷藏（4°C）短期保存。储备液可在4°C，pH 3-5下稳定保存6周。
Other Notes
Christner, C., et al. 1999.J. Med. Chem. 42, 3615.
Lu, Q., et al. 1996.Arch.Biochem.Biophys.334, 175.
Chow, S.C., et al. 1995.Exp.Cell Res.216, 149.
Cotter, T.G., et al. 1992.Anticancer Res.12, 773.
Takano, Y.S., et al. 1991.J. Pathol.163, 329.
Waring, P. 1990.J. Biol. Chem. 265, 14476.
Lu, Q., et al. 1996.Arch.Biochem.Biophys.334, 175.
Chow, S.C., et al. 1995.Exp.Cell Res.216, 149.
Cotter, T.G., et al. 1992.Anticancer Res.12, 773.
Takano, Y.S., et al. 1991.J. Pathol.163, 329.
Waring, P. 1990.J. Biol. Chem. 265, 14476.
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Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：高毒性 & 致癌性/致畸性（I）
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
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