239805
环匹阿尼酸，来源于灰黄青霉
A cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase that releases Ca2+ from the same intracellular pools as Thapsigargin.
别名:
环匹阿尼酸，来源于灰黄青霉, CPA
Quality Level
InChI
1S/C20H20N2O3/c1-9(23)14-18(24)17-16-11-8-21-13-6-4-5-10(15(11)13)7-12(16)20(2,3)22(17)19(14)25/h4-6,8,12,16-17,21,25H,7H2,1-3H3/t12-,16+,17+/m1/s1
InChI key
RLOAZVAJNNPPDI-DQYPLSBCSA-N
assay
≥97% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
DMSO: 1 mg/mL, chloroform: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
一种内质网Ca2+-ATPase的细胞可渗透，可逆抑制剂，可从与毒胡萝卜素相同的细胞内池中释放Ca2+。调动Ca2+而不增加Ins（1，4，5）P3水平。也已知抑制不同于肌动球蛋白ATPase的肌浆网状Ca2+-ATPase。Bay K 8644（目录编号196878）可以逆转环匹阿尼酸对因乙酰胆碱重复刺激而耗尽的Ca2+池补充的抑制作用。
Biochem/physiol Actions
主要靶标
培养的动脉肌肉细胞中Ca2+摄取
培养的动脉肌肉细胞中Ca2+摄取
产物不与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：560 nM抑制培养的动脉平滑肌细胞摄取Ca2+
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存3个月。
Other Notes
Badaoui, A., et al. 1995.J. Mol.Cell.Cardiol.27, 2495.
Elmoselli, A.B., et al. 1995.Mol.Cell.Biochem.151, 149.
Schaefer, A., et al. 1994.J. Biol. Chem.269, 8786.
Demaurex, N., et al. 1992.J. Biol. Chem.267, 2318.
Low, A.M., et al. 1992.Am. J. Physiol.262, H31.
Kurebayashi, N., and Ogawa, Y. 1991.J. Muscle Res. Cell Motil.12, 355.
Mason, M.J., et al. 1991.J. Biol. Chem.266, 20856.
Elmoselli, A.B., et al. 1995.Mol.Cell.Biochem.151, 149.
Schaefer, A., et al. 1994.J. Biol. Chem.269, 8786.
Demaurex, N., et al. 1992.J. Biol. Chem.267, 2318.
Low, A.M., et al. 1992.Am. J. Physiol.262, H31.
Kurebayashi, N., and Ogawa, Y. 1991.J. Muscle Res. Cell Motil.12, 355.
Mason, M.J., et al. 1991.J. Biol. Chem.266, 20856.
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Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：有毒（F）
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Mia S Geromella et al.
STAR protocols, 4(1), 101987-101987 (2023-01-06)
This protocol employs the indo-1 Ca2+ fluorophore to quantify Ca2+ uptake by the sarco(endo)plasmic reticulum Ca2+ ATPase pump in murine muscle homogenates and allows for real-time kinetic measurement of Ca2+ mobilization within the muscle homogenate. This protocol can be easily
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