239819
CXCR2 antagonist, Cpd 19
The CXCR2 antagonist, Cpd 19, also referenced under CAS 473728-67-5, controls the biological activity of CXCR2.
别名:
CXCR2 antagonist, Cpd 19, 3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide
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关于此项目
经验公式（希尔记法）:
C18H21N3O4
化学文摘社编号:
分子量:
343.38
MDL number:
NACRES:
NA.51
UNSPSC Code:
12352200
产品名称
CXCR2 antagonist, Cpd 19, The CXCR2 antagonist, Cpd 19, also referenced under CAS 473728-67-5, controls the biological activity of CXCR2.
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
DMSO: 50 mg/mL, light brown
shipped in
ambient
storage temp.
−20°C
Quality Level
Disclaimer
Toxicity: Regulatory Review (Z)
General description
A cell-permeable, cyclobutenedione derivative that acts as a potent antagonist of chemokine receptor CXCR2 (IL8RB) (IC50 = 8 nM). Reported to inhibit CXCR2-mediated chemotaxis in a CXCR2 expressing cell line (IC50 = 145 nM). Exhibits good stability in human and rat liver microsomal preparations (>50% remaining after 30 min at 37°C).
Other Notes
Merritt, J., et al. 2006. Bioorg. Med. Chem. Lett.16, 4107.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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