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Merck
CN

239836

Cyclophilin A Inhibitor

The Cyclophilin A Inhibitor, also referenced under CAS 1186372-20-2, controls the biological activity of Cyclophilin A. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

别名:

Cyclophilin A Inhibitor

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关于此项目

经验公式(希尔记法):
C21H14ClFN2O2
化学文摘社编号:
分子量:
380.80
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
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SMILES string

Fc1c(c(ccc1)Cl)C(=O)NC(=O)NC2c3c(cccc3)c4c2cccc4

InChI

1S/C21H14ClFN2O2/c22-16-10-5-11-17(23)18(16)20(26)25-21(27)24-19-14-8-3-1-6-12(14)13-7-2-4-9-15(13)19/h1-11,19H,(H2,24,25,26,27)

InChI key

SFNLLCUAISZNRV-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Tatsuya Tsuda et al.
Journal of pharmacological sciences, 142(3), 109-115 (2019-12-29)
Arterial calcification, a risk factor of cardiovascular events, develops with differentiation of vascular smooth muscle cells (VSMCs) into osteoblast-like cells. Cyclophilin A (CypA) is a peptidyl-prolyl isomerase involved in cardiovascular diseases such as atherosclerosis and aortic aneurysms, and rho-associated protein

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