260575
1--脱氧甘露伊霉素盐酸盐
A specific α-mannosidase I inhibitor that blocks conversion of high mannose to complex oligosaccharides.
别名:
1--脱氧甘露伊霉素盐酸盐, DMJ，1，5-二脱氧-1，5-亚氨基-D-甘露醇，HCl
InChI key
LXBIFEVIBLOUGU-KVTDHHQDSA-N
InChI
1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4-,5-,6-/m1/s1
assay
≥98% (TLC)
form
crystalline solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
ethanol: 1 mg/mL, water: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
一种阻断高甘露糖转化为复杂寡糖的特异性α-甘露糖苷酶I抑制剂。
Biochem/physiol Actions
主要靶标
α-甘露糖苷酶I
α-甘露糖苷酶I
产物不与ATP竞争。
可逆：否
细胞渗透性：否
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻长期保存（-20°C），或冷藏（4°C）短期保存。储备溶液在4°C下可稳定保存1个月，在-20°C下可稳定保存6个月。
Other Notes
Suzuki, S.S., and Piette, L.H.1993.J. Cell.Biochem.51, 181.
Fuhrmann, U., et al. 1984.Nature307, 755.
Fuhrmann, U., et al. 1984.Nature307, 755.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：有害（C）
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
S S Suzuki et al.
Journal of cellular biochemistry, 51(2), 181-189 (1993-02-01)
The mouse embryo fibroblast cell line, C3H/10T1/2, synthesized and deposited a large amount of fibronectin especially in the pericellular matrix. Confluent cultures of these cells cultured in the presence of 0.3 micrograms/ml of retinyl acetate released cell surface fibronectin and
U Fuhrmann et al.
Nature, 307(5953), 755-758 (1984-02-23)
Many secretory and membrane proteins are glycoproteins carrying asparagine-linked (N-linked) oligosaccharides. There are two types of N-linked glycans, referred to as high-mannose and complex type, respectively. Biosynthesis of N-linked glycans of the complex type proceeds via a high-mannose intermediate. After
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