260684
1-Deoxynojirimycin, Hydrochloride - CAS 73285-50-4 - Calbiochem
A specific glucosidase inhibitor including trimming glucosidases I and II, enzymes that sequentially remove the three glucose residues from precursor Glc3Man9-GlcNAc2 in N-linked glycan biosynthesis.
别名:
1-Deoxynojirimycin, Hydrochloride - CAS 73285-50-4 - Calbiochem, DNJ, HCl
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关于此项目
经验公式（希尔记法）:
C6H13NO4 · xHCl
化学文摘社编号:
分子量:
163.17 (free base basis)
UNSPSC Code:
12352200
MDL number:
assay
≥98% (TLC)
form
crystalline solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
solubility
water: 100 mM
shipped in
ambient
Quality Level
General description
A specific glucosidase inhibitor including trimming glucosidases I and II, enzymes that sequentially remove the three glucose residues from precursor Glc3Man9-GlcNAc2 in N-linked glycan biosynthesis.
Specific glucosidase inhibitor, including trimming glucosidases I and II, that sequentially removes the three glucose residues from precursor Glc3Man9GlcNAc2 in N-linked glycan biosynthesis.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Glucosidase 1, glucosidase 2
Glucosidase 1, glucosidase 2
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Suh, K., et al. 1992. J. Biol. Chem. 267, 21671.
Fuhrmann, U., et al. 1985. Biochim. Biophys. Acta825, 95.
Fuhrmann, U., et al. 1985. Biochim. Biophys. Acta825, 95.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
K Suh et al.
The Journal of biological chemistry, 267(30), 21671-21677 (1992-10-25)
The role of glucosylated oligosaccharides in the biogenesis of the glycoprotein (G protein) of vesicular stomatitis virus was studied in PhaR2.7, a mouse lymphoma cell line deficient in glucosidase II activity. As expected, the great majority of cell-associated G protein
Inhibitors of oligosaccharide processing.
U Fuhrmann et al.
Biochimica et biophysica acta, 825(2), 95-110 (1985-06-24)
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