310500
D-erythro-Sphingosine, N,N-Dimethyl-
A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC50 = 12 µM) and stimulates Src kinase activity.
别名:
D-erythro-Sphingosine, N,N-Dimethyl-, DMS, SK Inhibitor III, Sphingosine Kinase Inhibitor III
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C20H41NO2
化学文摘社编号:
分子量:
327.55
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.77
Quality Level
assay
≥98% (TLC)
form
oil (Clear), waxy solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
DMSO: 5 mg/mL, ethanol: soluble, methanol: soluble
shipped in
ambient
storage temp.
−20°C
SMILES string
N([C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO)(C)C
InChI
1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1
InChI key
YRXOQXUDKDCXME-YIVRLKKSSA-N
General description
A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC50 = 12 µM) and stimulates Src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells. An inhibitor of sphingosine kinase.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PKC
PKC
Product does not compete with ATP.
Reversible: yes
Target IC50: 12 µM against PKC
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
Other Notes
Cuvillier, O., et al. 1996. Nature381, 800.
Ohta, H., et al. 1995. Cancer Res.55, 691.
Kimura, S., et al. 1992. Biochem. Pharmacol.44, 1585.
Hanada, K., et al. 1991. Biochemistry30, 11682.
Igarashi, Y., et al. 1990. J. Biol. Chem.265, 5385.
Ohta, H., et al. 1995. Cancer Res.55, 691.
Kimura, S., et al. 1992. Biochem. Pharmacol.44, 1585.
Hanada, K., et al. 1991. Biochemistry30, 11682.
Igarashi, Y., et al. 1990. J. Biol. Chem.265, 5385.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Grégory Lavieu et al.
Methods in molecular biology (Clifton, N.J.), 445, 159-173 (2008-04-22)
Sphingolipids are constituents of biological membranes. Ceramide and sphingosine 1-phosphate (S1P) also act as second messengers and are part of a rheostat system, in which ceramide promotes cell death and growth arrest, and S1P induces proliferation and maintains cell survival.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 310500-5MG | 04055977216837 |