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311203

N^G,N^G-Dimethyl-L-arginine, Dihydrochloride

Name: N<sup>G</sup>,N<sup>G</sup>-Dimethyl-L-arginine, Dihydrochloride
Brand: MM

A cell-permeable, reversible inhibitor of nitric oxide synthase in vitro (IC₅₀ = 2-3 µM) and in vivo.

别名:

ADMA, 2HCl, N^G,N^G-Dimethyl-L-arginine, Dihydrochloride

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关于此项目

经验公式（希尔记法）:

C₈H₁₈N₄O₂ · 2HCl

化学文摘社编号:

220805-22-1

分子量:

275.18

MDL number:

MFCD00270857

UNSPSC Code:

12352209

NACRES:

NA.77

Assay:

≥98% (TLC)

Form:

amorphous solid

Storage condition:

OK to freeze, desiccated (hygroscopic)

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属性

Quality Segment

100

assay

≥98% (TLC)

form

amorphous solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

water: 50 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

Cl.Cl.N[C@@H](CCCN=C(N(C)C)N)C(=O)O

InChI

1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1

InChI key

SYLNVYJOPZWPJI-ILKKLZGPSA-N

说明

General description

A cell-permeable, reversible inhibitor of nitric oxide synthase in vitro (IC₅₀ = 2-3 µM) and in vivo. Causes dose-dependent vasoconstriction and bradycardic effects.

Endogenous reversible inhibitor of nitric oxide synthesis in vitro and in vivo. Causes dose-dependent vasoconstriction and bradycardic effects.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
NOS in vitro

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 2-3 µM inhibiting nitric oxide synthase in vitro

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Other Notes

Closs, E.I., et al. 1997. Nitric Oxide1, 65.
Faraci, F.M., et al. 1995. Am. J. Physiol.269, H1522.
Gardiner, S.M., et al. 1993. Br. J. Pharmacol. 110, 1457.
Kotani, K., et al. 1992. J. Neurochem.58, 1127.
Vallance, P., et al. 1992. Lancet339, 572.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c