323115
DNA Repair Pathway Inhibitor, NS-123 - CAS 101860-83-7 - Calbiochem
别名:
DNA Repair Pathway Inhibitor, NS-123 - CAS 101860-83-7 - Calbiochem, 4ʹ-Bromo-3ʹ-nitropropiophenone, Radiation Sensitizer, NS-123
InChI key
TZELZSUMAATQRO-UHFFFAOYSA-N
InChI
1S/C9H8BrNO3/c1-2-9(12)6-3-4-7(10)8(5-6)11(13)14/h3-5H,2H2,1H3
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
General description
A cell-permeable nitro-propiophenone compound that preferentially enhances tumor growth-inhibitory effects of ionizing radiation (~ 5 µM in U251, HT-29 and A549 tumor cells and in U251 xenograft mouse model, 50 mg/kg, i.p.) with no apparent effect on normal human glial cells, Zebrafish embryos and nude mice. Shown to increase the accumulation of unrepaired double-strand DNA breaks and prolong the damage-dependent signaling.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Lally, B.E., et al. 2007. Cancer Res.67, 8791.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
10-13 - German Storage Class 10 to 13
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