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324623

Eg5 Inhibitor IV, VS-83

Name: Eg5 Inhibitor IV, VS-83
Brand: MM

The Eg5 Inhibitor IV, VS-83, also referenced under CAS 909250-29-9, controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications.

别名:

Eg5 Inhibitor IV, VS-83, 5-Fluoro-3,4-dihydro-4(3ʹ-hydroxyphenyl)quinazoline-2(1H)-thione

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关于此项目

经验公式（希尔记法）:

C₁₄H₁₁FN₂OS

化学文摘社编号:

909250-29-9

分子量:

274.31

MDL number:

MFCD28138121

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥99% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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属性

Quality Level

100

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

ethanol: 5 mg/mL, DMSO: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

Fc1c2c(ccc1)NC(=S)NC2c3cc(ccc3)O

InChI

1S/C14H11FN2OS/c15-10-5-2-6-11-12(10)13(17-14(19)16-11)8-3-1-4-9(18)7-8/h1-7,13,18H,(H2,16,17,19)

InChI key

MAEYCDNDKNPNQJ-UHFFFAOYSA-N

说明

General description

A cell-permeable Monastrol (Cat. No. 475879) analog with much enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC₅₀ = 1.17 vs. 20.73 µM for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC₅₀ = 7.27 vs. 58.74 µM for BSC-1 cells treated with VS-83 and Monastrol, respectively). Shown to exhibit ≥10-fold antiproliferative activity than Monastrol against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Muller, C., et al. 2007. Cancer Chemother. Pharmacol.59, 157.
Santamaria, A., et al. 2007. Mol. Biol. Cell18, 4024.
Sarli, V., et al. 2005. ChemBioChem6, 2005.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Regulatory Review (Z)

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c