324888
Epigenetic Multiple Ligand
A cell-permeable bis-arylidene compound that acts as an epigenetic multiple ligand (epi-ML) and inhibits substrates processing by several chromatin-associated enzymes.
别名:
Epigenetic Multiple Ligand, 3,5-bis(3,5-Dibromo-4-hydroxybenzylidene)-tetrahydro-2H-pyran-4-one, PRMT Inhibitor IV
质量水平
方案
≥97% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
light orange
溶解性
DMSO: 100 mg/mL
运输
ambient
储存温度
2-8°C
一般描述
A cell-permeable bis-arylidene compound that acts as an epigenetic multiple ligand (epi-ML) and inhibits substrates processing by several chromatin-associated enzymes, including H4/PRMT1 (91% inhibition at 50 µM), H4/RmtA (50% inhibition at 29 µM), H3/p300/CBP (61% inhibition at 50 µM), PABP1/CARM1 (>90% inhibition at 100 µM), H3/SET7 (>90% inhibition at 100 µM), SIRT1/2 (>50% inhibition at 25 µM), although the process of Np13p by PRMT1 is only weakly affected. Shown to induce either apoptosis (28% after 30 h incubation with 25 µM inhibitor) or granulocytic differentiation (100% of non-apoptotic cells after 30 hr incubation with 5 µM inhibitor) among U937 cell population.
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Mai, A., et al. 2008. J. Med. Chem.51, 2279.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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