A cell-permeable Erk Inhibitor II (Cat. No. 328007) structural analog that acts as a isoform-selective Aurora B kinase inhibitor (95% inhibition at 1 µM; [ATP] = 10 µM) with little or no activity against Aurora A or C (0% and 16% inhibition, respectively, at 1 µM; [ATP] = 15 µM), Also shown to inhibit Chk2, IRR/INSRR, and Ack1/TNK2 (% inhibition/[ATP] = 81%/70 µM, 75%/200 µM, and 71%/70 µM, respectively), while exhibiting much reduced or no inhibitory potency toward a panel of 228 other kinases, including Erk1/2.

Cell permeable: yes

Primary Target
Aurora B kinase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 95% inhibition at 10 µM using 1 µM; [ATP]

Packaged under inert gas

Anastassiadis, T., et al. 2013. J. Biol. Chem.288, In press.
Gao, Y., et al. 2013. Biochem. J.in press.
Ohori, M., et al. 2005. Biochem. Biophys. Res. Commun.336, 357.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)