328008
ERK Inhibitor II, Negative Control, FR180209
The ERK Inhibitor II, Negative Control, also referenced under CAS 1177970-73-8, controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
ERK Inhibitor II, Negative Control, FR180209, 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ol, Chk2 Inhibitor IV, Irfin1, Insulin Receptor Family Inhibitor, Aurora Kinase Inhibitor XII
InChI key
QMBDONCHHMIWFJ-UHFFFAOYSA-N
InChI
1S/C18H12N6O/c25-18-12-10-13(19-20-17(12)21-22-18)15-14-8-4-5-9-24(14)23-16(15)11-6-2-1-3-7-11/h1-10H,(H2,20,21,22,25)
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
green
solubility
DMSO: 10 mg/mL
shipped in
ambient
Quality Level
General description
A cell-permeable Erk Inhibitor II (Cat. No. 328007) structural analog that acts as a isoform-selective Aurora B kinase inhibitor (95% inhibition at 1 µM; [ATP] = 10 µM) with little or no activity against Aurora A or C (0% and 16% inhibition, respectively, at 1 µM; [ATP] = 15 µM), Also shown to inhibit Chk2, IRR/INSRR, and Ack1/TNK2 (% inhibition/[ATP] = 81%/70 µM, 75%/200 µM, and 71%/70 µM, respectively), while exhibiting much reduced or no inhibitory potency toward a panel of 228 other kinases, including Erk1/2.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Aurora B kinase
Aurora B kinase
Product does not compete with ATP.
Reversible: no
Target IC50: 95% inhibition at 10 µM using 1 µM; [ATP]
Packaging
Packaged under inert gas
Other Notes
Anastassiadis, T., et al. 2013. J. Biol. Chem.288, In press.
Gao, Y., et al. 2013. Biochem. J.in press.
Ohori, M., et al. 2005. Biochem. Biophys. Res. Commun.336, 357.
Gao, Y., et al. 2013. Biochem. J.in press.
Ohori, M., et al. 2005. Biochem. Biophys. Res. Commun.336, 357.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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