328009
ERK Inhibitor III
The ERK Inhibitor III, also referenced under CAS 331656-92-9, controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
ERK Inhibitor III
质量水平
方案
≥85% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
yellow
溶解性
DMSO: 10 mg/mL
运输
ambient
储存温度
2-8°C
一般描述
A cell-permeable furanyl-nitroaminoguanidine ERK-binding (KD of ~13 µM) compound that acts as a substrate-, but not ATP-, site-targeting inhibitor of ERK. Selectively inhibits the EGF-stimulated cellular phosphorylation of ERK substrates Rsk-1 and Elk-1, but not that of ERK1/2 or the anisomycin-induced phosphorylation of the p38 substrate ATP-2 in HeLa cells.
生化/生理作用
Cell permeable: yes
KD = ~13 µM against ERK
Primary Target
ERK
ERK
Product does not compete with ATP.
Reversible: no
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Chen, F., et al. 2006. Bioorg. Med. Chem. Lett.16, 6281.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Irritant (B)
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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