Name: EST
Brand: MM

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About This Item

经验公式（希尔记法）:

C₁₇H₃₀N₂O₅

CAS Number:

88321-09-9

分子量:

342.43

MDL编号:

MFCD00132883

UNSPSC代码:

12352200

NACRES:

NA.77

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质量水平

100

描述

RTECS - RR0404300

方案

≥97% (HPLC)

表单

solid

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze

颜色

white

溶解性

DMSO: soluble

运输

ambient

储存温度

−20°C

SMILES字符串

N([C@@H](CC(C)C)C(=O)NCCC(C)C)C(=O)[C@H]1O[C@@H]1C(=O)OCC

InChI

1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1

InChI key

SRVFFFJZQVENJC-IHRRRGAJSA-N

一般描述

A cell-permeable, irreversible inhibitor of cysteine proteases. Similar to E-64 (Cat. No. 324890) but devoid of charged groups. Reported to inhibit calpain-1 activation. The inhibitory activity of EST has been attributed to E-64c, the free acid formed by hydrolysis of the ester in vivo. Used in animal models of muscular dystrophy.

生化/生理作用

Cell permeable: yes

Primary Target
calpain-1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 10-100 µM for calpain-1

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.

其他说明

Inomata, M., et al. 1996. Arch. Biochem. Biophys. 328, 129.
Mehdi, S. 1991. Trends Biochem. Sci. 16, 150.
McGowan, E.B., et al. 1989. Biochem. Biophys. Res. Commun.158, 432.
Tamai, M., et al. 1987. J. Pharmacobiodyn.10, 678.
Komatsu, K., et al. 1986. Exp. Neurol. 91, 23.
Tamai, M., et al. 1986. J. Pharmacobiodyn. 9, 672.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)