341251
Fascaplysin, Synthetic
A cell-permeable red pigment, originally isolated from marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/D1 (IC50 = 0.35 µM).
别名:
Fascaplysin, Synthetic
InChI key
PWUOOJVYZQILBG-UHFFFAOYSA-N
InChI
1S/C18H10N2O.ClH/c21-18-13-6-2-4-8-15(13)20-10-9-12-11-5-1-3-7-14(11)19-16(12)17(18)20;/h1-10H;1H
assay
≥98% (NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
brown
solubility
methanol: 1 mg/mL, DMSO: 10 mg/mL
shipped in
ambient
Quality Level
General description
A cell-permeable red pigment, originally isolated from a species of marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/cyclin D1 (IC50 = 350 nM). Reported to inhibit Cdk6/cyclin D1 with much lower potency (IC50 = 3.4 µM). Exhibits little to no effect on the activities of several other Cdk′s (IC50 >20 µM) and tyrosine kinases (IC50 >10 µM). Biological effects are attributed, in part, to its ability to intercalate into DNA. Also displays anti-microbial activity.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
CDK4/D1
CDK4/D1
Product competes with ATP.
Reversible: yes
Target IC50: 0.35 µM against Cdk4/D1
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Hormann, A., et al. 2001. Bioorg. Med. Chem.9, 917.
Kirsch, G., et al. 2000. J. Nat. Prod.63, 825.
Soni, R., et al. 2000. Biochem. Biophys. Res. Commun.275, 877.
Kirsch, G., et al. 2000. J. Nat. Prod.63, 825.
Soni, R., et al. 2000. Biochem. Biophys. Res. Commun.275, 877.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Toxic (F)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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