341305
Fasentin
别名:
Fasentin, 6094911, N-(4-Chloro-3-(trifluoromethyl)phenyl)-3-oxobutanamide, Glucose Transporter Inhibitor, Glucose Transporter Inhibitor, 6094911, N-(4-Chloro-3-(trifluoromethyl)phenyl)-3-oxobutanamide
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C11H9ClF3NO2
化学文摘社编号:
分子量:
279.64
UNSPSC Code:
12352200
NACRES:
NA.54
MDL number:
form
solid
SMILES string
FC(F)(F)c1c(ccc(c1)NC(=O)CC(=O)C)Cl
InChI
1S/C11H9ClF3NO2/c1-6(17)4-10(18)16-7-2-3-9(12)8(5-7)11(13,14)15/h2-3,5H,4H2,1H3,(H,16,18)
InChI key
GNYIJZMBLZXJEJ-UHFFFAOYSA-N
assay
≥95% (HPLC)
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 20 mg/mL
shipped in
ambient
Quality Level
正在寻找类似产品? 访问 产品对比指南
General description
A cell-permeable oxobutananilide compound that is predicted to interact with Glut (Glucose Transporter) at an intracellular site based on a virtual docking study and shown to inhibit Glut-mediated cellular glucose uptake (50% and 80% inhibition of 2-deoxy-D-glucose uptake in Glut1- and Glut4-overexpressing L6 myoblasts, respectively, at 300 µM). Fas-resistant cell lines that are made Fas-responsive upon medium glucose deprivation are also shown to be sensitized by Fasentin to Fas-mediated cell death (ED50 = 35 µM in PPC-1 cultures), while cells that remain Fas-resistant upon glucose deprivation, e.g. DU145, are shown not to be sensitized by Fasentin to Fas-mediated death.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -2°C.
Other Notes
Wood, T.E., et al. 2008. Mol. Cancer Ther.7, 3546
Schimmer, A.D., et al. 2006. Cancer Res.66, 2367.
Schimmer, A.D., et al. 2006. Cancer Res.66, 2367.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持