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Merck
CN

341609

Sigma-Aldrich

FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 - CAS 949164-80-1 - Calbiochem

The FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 controls the biological activity of FGF Receptor Tyrosine KInase. Primarily used for Phosphorylation & Dephosphorylation applications.

别名:

FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 - CAS 949164-80-1 - Calbiochem, (Z)-3-(5-(6-(3,5-Dimethoxyphenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrol-3-yl)-propionic acid, NP603, PDGFR Tyrosine Kinase Inhibitor XVI, VEGFR Tyrosine Kinase Inhibitor XXIX, VEGFR2 Kinase Inhibitor XXVII, PDGFR Tyrosine Kinase Inhibitor XVI, (Z)-3-(5-(6-(3,5-Dimethoxyphenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrol-3-yl)-propionic acid, NP603, VEGFR Tyrosine Kinase Inhibitor XXIX, VEGFR2 Kinase Inhibitor XXVII

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关于此项目

经验公式（希尔记法）:
C26H26N2O5
化学文摘社编号:
949164-80-1
分子量:
446.50
MDL编号:
MFCD18632551
UNSPSC代码:
12352200

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质量水平

100

方案

≥97% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

orange

溶解性

DMSO: 100 mg/mL

运输

ambient

储存温度

2-8°C

一般描述

A cell-permeable SU6668 (PDGFR Tyrosine Kinase Inhibitor VI, Cat. No. 521235) derivative that targets the ATP-binding pocket and inhibits the kinase activity of FGFR1, PDGFRβ, and VEGFR2 (IC50 = 520, 780, and 930 nM, respectively), while exhibiting little activity against EGFR (IC50 >100 µM). Shown to exhibit anti-angiogenesis activity and suppress FGF-2-induced proliferation (IC50 = 18.2 µM) in HUVEC cultures in a dose-dependent manner.
A cell-permeable SU6668 (PDGFR Tyrosine Kinase Inhibitor VI, Cat. No. 521235) derivative that targets the ATP-binding pocket and inhibits the kinase activity of FGFR1, PDGFRβ, and VEGFR2 (IC50 = 520, 780, and 930 nM, respectively), while exhibiting little activity against EGFR (IC50 >100 µM). Shown to exhibit anti-angiogenesis activity and suppress FGF-2-induced proliferation (IC50 = 18.2 µM) in HUVEC cultures in a dose-dependent manner.

包装

Packaged under inert gas

制备说明

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Kammasud, N., et al. 2009. Bioorg. Med. Chem. Lett.19, 745.
Kammasud, N., et al. 2007. Bioorg. Med. Chem. Lett.17, 4812.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Harmful (C)

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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