341609
FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 - CAS 949164-80-1 - Calbiochem
The FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 controls the biological activity of FGF Receptor Tyrosine KInase. Primarily used for Phosphorylation & Dephosphorylation applications.
别名:
FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 - CAS 949164-80-1 - Calbiochem, (Z)-3-(5-(6-(3,5-Dimethoxyphenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrol-3-yl)-propionic acid, NP603, PDGFR Tyrosine Kinase Inhibitor XVI, VEGFR Tyrosine Kinase Inhibitor XXIX, VEGFR2 Kinase Inhibitor XXVII, PDGFR Tyrosine Kinase Inhibitor XVI, (Z)-3-(5-(6-(3,5-Dimethoxyphenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrol-3-yl)-propionic acid, NP603, VEGFR Tyrosine Kinase Inhibitor XXIX, VEGFR2 Kinase Inhibitor XXVII
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
orange
solubility
DMSO: 100 mg/mL
shipped in
ambient
Quality Level
General description
A cell-permeable SU6668 (PDGFR Tyrosine Kinase Inhibitor VI, Cat. No. 521235) derivative that targets the ATP-binding pocket and inhibits the kinase activity of FGFR1, PDGFRβ, and VEGFR2 (IC50 = 520, 780, and 930 nM, respectively), while exhibiting little activity against EGFR (IC50 >100 µM). Shown to exhibit anti-angiogenesis activity and suppress FGF-2-induced proliferation (IC50 = 18.2 µM) in HUVEC cultures in a dose-dependent manner.
A cell-permeable SU6668 (PDGFR Tyrosine Kinase Inhibitor VI, Cat. No. 521235) derivative that targets the ATP-binding pocket and inhibits the kinase activity of FGFR1, PDGFRβ, and VEGFR2 (IC50 = 520, 780, and 930 nM, respectively), while exhibiting little activity against EGFR (IC50 >100 µM). Shown to exhibit anti-angiogenesis activity and suppress FGF-2-induced proliferation (IC50 = 18.2 µM) in HUVEC cultures in a dose-dependent manner.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Kammasud, N., et al. 2009. Bioorg. Med. Chem. Lett.19, 745.
Kammasud, N., et al. 2007. Bioorg. Med. Chem. Lett.17, 4812.
Kammasud, N., et al. 2007. Bioorg. Med. Chem. Lett.17, 4812.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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