343020
Flt-3 Inhibitor
The Flt-3 Inhibitor, also referenced under CAS 301305-73-7, controls the biological activity of Flt-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Flt-3 Inhibitor
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C18H20N2O4S
化学文摘社编号:
分子量:
360.43
UNSPSC Code:
12352106
NACRES:
NA.77
MDL number:
SMILES string
[s]1c2c(c(c1NC(=O)c3cc(c(cc3)OC)OC)C(=O)N)CCCC2
InChI
1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)
InChI key
FSPQCTGGIANIJZ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 10 mg/mL
shipped in
ambient
Quality Level
General description
A cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor (IC50 = 42 nM) with little effect against a panel of 22 other kinases (IC50 ≥3 µM). Shown to exhibit antiproliferative properties against the human acute myelogenous leukemia cell line MV4-11 (IC50 = 340 nM) expressing constitutively active Flt-3.
Biochem/physiol Actions
Cell permeable: yes
Product competes with ATP.
Reversible: no
Target IC50: 42 nM against Flt-3
Packaging
Packaged under inert gas
Other Notes
Patch, R.J., et al. 2006. Bioorg. Med. Chem. Lett.16, 3282.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
存储类别
11 - Combustible Solids
wgk
WGK 3
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持