343022
Flt-3 Inhibitor III
The Flt-3 Inhibitor III, also referenced under CAS 852045-46-6, controls the biological activity of Flt-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Flt-3 Inhibitor III, (5-Phenyl-thiazol-2-yl)-(4-(2-pyrrolidin-1-yl-ethoxy)-phenyl)-amine, 5-Phenyl-N-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)-2-thiazolamine, 5-Phenyl-N-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)-2-thiazolamine, (5-Phenyl-thiazol-2-yl)-(4-(2-pyrrolidin-1-yl-ethoxy)-phenyl)-amine
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
DMSO: 10 mg/mL
运输
ambient
储存温度
−20°C
一般描述
A cell-permeable 5-phenyl-2-thiazolamine compound that acts as a potent, ATP binding site-targeting inhibitor of Flt3 (IC50 = 50 nM). It inhibits c-Kit, KDR, c-Abl, Cdk1, c-Src, and Tie-2 only at much higher concentrations (IC50 = 0.26, 0.91, 1.2, 2.1, 2.8, and 8.0 µM, respectively) and exhibits little activity against a panel of 12 other commonly studied kinases even at concentrations as high as 10 µM. Blocks FLT3-dependent cell proliferation in a dose-dependent manner (IC50 = 52, 240, and 760 nM in MV4:11-ITD, BaF3-ITD, and BaF3-D835/Y cells).
生化/生理作用
Cell permeable: yes
Primary Target
Flt-3
Flt-3
Product competes with ATP.
Reversible: no
Target IC50: 50 nM against Flt3
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Furet, P., et al. 2006. J. Med. Chem.49, 4451.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Harmful (C)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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