FPT Inhibitor I

A highly selective and potent inhibitor of Ras farnesyltransferase (IC₅₀ = 83 nM). Inhibits geranylgeranyltransferase I (IC₅₀ = 26 µM) and II (IC₅₀ = 47 µM) at much higher concentrations.

Potent and highly selective inhibitor of farnesyltransferase (FTase; IC₅₀ = 83 nM). Inhibits geranylgeranyltransferase (GGTase) I and II at much higher concentrations (IC₅₀ = 26 µM and 47 µM for GGTase I and II, respectively).

The FPT Inhibitor I controls the biological activity of FPT. This small molecule/inhibitor is primarily used for Cancer applications.

Primary Target
Farnesyltransferase (Ftase)

Product does not compete with ATP.

Target IC₅₀: 83 nM against Ftase

Packaged under inert gas

Following reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 4 months at -70°C.

Manne, V., et al. 1995. Drug Development Res.34, 121.
Patel, D.V., et al. 1995. J. Med. Chem.38, 2906.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)