344281-M
Forskolin, NKH477
A cell-permeable and water-soluble Forskolin derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC.
别名:
Forskolin, NKH477, 6-(3-Dimethylaminopropionyl)forskolin, HCl, Colforsin Daropate, HCl
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C27H43NO8 · xHCl
化学文摘社编号:
分子量:
509.63 (free base basis)
UNSPSC Code:
12352200
MDL number:
InChI
1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1
InChI key
VIRRLEDAYYYTOD-YHEOSNBFSA-N
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
water: 10 mg/mL
Quality Level
General description
A cell-permeable and water-soluble Forskolin (Cat. No. 344270 ) derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC (1.04- & 0.89-fold relative to Forskolin). NKH477 is shown to be orally available, blood-brain barrier permeant, and display reactivity toward a broad-spectrum of species, including human, canine, guinea pig, murine, procine, and rat.
Other Notes
Nakashima, S., et al. 2005. J. Heart Lung Transplant.24, 462.
Morinobu, S., et al. 1999. J. Neurochem.72, 2198.
Satake, K., et al. 1998. Br. J. Pharmacol.123, 753.
Toya, Y., et al. 1998. J. Mol. Cell Cardiol.30, 97.
Takeuchi, M., et al. 1995. Cardiovasc. Drug Rev.13, 339.
Hosono, M., et al. 1992. J. Cardiovasc. Pharmacol.19, 625.
Shafiq, J., et al. 1992. Circ. Res.71, 70.
Hosono, M., et al. 1990. Eur. J. Pharmacol.183, 2110.
Morinobu, S., et al. 1999. J. Neurochem.72, 2198.
Satake, K., et al. 1998. Br. J. Pharmacol.123, 753.
Toya, Y., et al. 1998. J. Mol. Cell Cardiol.30, 97.
Takeuchi, M., et al. 1995. Cardiovasc. Drug Rev.13, 339.
Hosono, M., et al. 1992. J. Cardiovasc. Pharmacol.19, 625.
Shafiq, J., et al. 1992. Circ. Res.71, 70.
Hosono, M., et al. 1990. Eur. J. Pharmacol.183, 2110.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Highly Toxic (H)
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持