跳转至内容
Merck
CN

353905

谷胱甘肽单乙酯

>90% (TLC), solid, GSH-MEE transport, Calbiochem®

别名:

谷胱甘肽单乙酯, γ-GCE,L-γ-谷氨酰-L-半胱氨酰甘氨酸乙酯,GSH-MEE

登录 查看组织和合同定价。

选择尺寸


关于此项目

经验公式(希尔记法):
C12H21N3O6S
化学文摘社编号:
分子量:
335.38
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.77
技术服务
需要帮助?我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助?我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

谷胱甘肽单乙酯, Cell-permeable derivative of glutathione (GSH) that undergoes hydrolysis by intracellular esterases to release GSH.

SMILES string

SC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)OCC

InChI

1S/C12H21N3O6S/c1-2-21-10(17)5-14-11(18)8(6-22)15-9(16)4-3-7(13)12(19)20/h7-8,22H,2-6,13H2,1H3,(H,14,18)(H,15,16)(H,19,20)/t7-,8-/m0/s1

InChI key

JKRODHBGNBKZLE-YUMQZZPRSA-N

assay

>90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

General description

谷胱甘肽(GSH)的细胞渗透性衍生物,通过细胞内酯酶水解,从而增加许多组织和细胞类型中细胞内GSH的浓度。GSH-MEE的有效运输已用于保护细胞免受辐射,氧化剂和各种有毒化合物(包括重金属)的损害。一种防止细胞损伤(如白内障和线粒体变性)的保护剂。

Biochem/physiol Actions

主要靶标
GSH-MEE的有效运输
产物不与ATP竞争。
可逆:否
细胞渗透性:否

Packaging

用惰性气体包装

Preparation Note

复溶后,等分并冷冻保存(-20°C)。溶液中不稳定;仅在使用前进行复溶。

Other Notes

Grattagliano, I., et al. 1995.J. Pharmacol.Exp.Ther.272, 484.
Martensson, J., et al. 1993.Proc.Natl.Acad.Sci. USA 90, 317.
Anderson, M.E., and Meister, A. 1989.Anal.Biochem.183, 16.
Anderson, M.E., et al. 1985.Arch.Biochem.Biophys.239, 538.
Wellner, V.P., et al. 1984.Proc.Natl.Acad.Sci. USA 81, 4732.
Puri, R.N., and Meister, A. 1983.Proc.Natl.Acad.Sci. USA 80, 5258.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性:标准处理(A)

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

相关内容

"Aging: getting older, exhibiting the signs of age, the decline in the physical (and mental) well-being over time, leading to death. Since the beginning of time, man has been obsessed with trying to slow down, stop, or even reverse the signs of aging. Many have gone as far as experimenting with nutritional regimens, eccentric exercises, fantastic rituals, and naturally occurring or synthetic wonder-elements to evade the signs of normal aging. Biologically speaking, what is aging? And what does the latest research tell us about the possibility of discovering the elusive “fountain of youth”? Many advances in our understanding of aging have come from systematic scientific research, and perhaps it holds the key to immortality. Scientifically, aging can be defined as a systems-wide decline in organismal function that occurs over time. This decline occurs as a result of numerous events in the organism, and these events can be classified into nine “hallmarks” of aging, as proposed by López-Otin et al. (2013). Several of the pathologies associated with aging are a direct result of these events going to extremes and may also involve aberrant activation of proliferation signals or hyperactivity. The hallmarks of aging have been defined based on their fulfillment of specific aging related criteria, such as manifestation during normal aging, acceleration of aging if experimentally induced or aggravated, and retardation of aging if prevented or blocked, resulting in increased lifespan. The nine hallmarks of aging are genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. The biological processes underlying aging are complex. By understanding the hallmarks in greater detail, we can get closer to developing intervention strategies that can make the aging process less of a decline, and more of a recline."

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持