361547
GSK-3β Inhibitor VI
The GSK-3β Inhibitor VI, also referenced under CAS 62673-69-2, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
GSK-3β Inhibitor VI, 2-Chloro-1-(4,5-dibromo-thiophen-2-yl)-ethanone
质量水平
方案
≥90% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
orange
溶解性
ethanol: 1 mg/mL
DMSO: 5 mg/mL (Use fresh, anhydrous DMSO only.)
运输
wet ice
储存温度
−20°C
InChI
1S/C6H3Br2ClOS/c7-3-1-5(4(10)2-9)11-6(3)8/h1H,2H2
InChI key
KYVDGDMQERQKOY-UHFFFAOYSA-N
一般描述
A cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC50 = 1 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.
A thienyl α-chloromethyl ketone compound that acts as a cell-permeable, irreversible, and non-ATP competitive inhibitor of GSK-3β (IC50 = 1 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.
生化/生理作用
Cell permeable: yes
Product does not compete with ATP.
Reversible: yes
Target IC50: 1 µM against Gsk-3β
包装
Packaged under inert gas
制备说明
Following reconstitution in DMSO, aliquot and freeze (-20°). DMSO stock solutions are stable for up to 1 week at -20°C. For increased stability reconstitute in chloroform, aliquot, dry under a stream of inert gas, and freeze (-20°C). Reconstitute in fresh DMSO just prior to use.
其他说明
Conde, S., et al. 2003. J. Med. Chem.46, 4631.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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