assay
≥95% (HPLC)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
DMSO: 25 mg/mL
shipped in
ambient
storage temp.
−20°C
InChI
1S/C27H33N3O4/c1-17(2)13-20(15-25(31)32)26(33)30-24(14-21-16-28-23-12-8-7-11-22(21)23)27(34)29-18(3)19-9-5-4-6-10-19/h4-12,16-18,20,24,28H,13-15H2,1-3H3,(H,29,34)(H,30,33)(H,31,32)/t18-,20+,24-/m0/s1
InChI key
BLPWNGOQQLJQOL-NRYAXDJKSA-N
General description
This product has been discontinued.
A potent broad-range inhibitor of matrix metalloproteinases (MMPs). Inhibits MMPs in vitro (Ki = 0.2 nM for MMP-1; Ki = 500 nM for MMP-2; Ki = 20 µM for MMP-3; Ki = 100 nM for MMP-8; and Ki = 100 nM for MMP-9). Also reduces the inflammatory and the hyperproliferative responses that occur following topical phorbol ester application.
A potent broad-spectrum inhibitor of matrix metalloproteinases (MMPs). Inhibits MMPs in vitro [Ki = 0.2 nM for interstitial collagenase (MMP-1); Ki = 500 nM for gelatinase A (MMP-2); Ki = 20 µM for stromelysin (MMP-3); Ki = 100 nM for neutrophil collagenase (MMP-8); Ki = 100 nM for gelatinase B (MMP-9)]. Also reduces the inflammatory and the hyperproliferative responses that occur following topical phorbol ester application.
Biochem/physiol Actions
Cell permeable: no
Primary Target
MMP-1
MMP-1
Product does not compete with ATP.
Reversible: no
Target Ki: 0.2 nM for MMP-1; 500 nM for MMP-2; 20 µM for MMP-3; 100 nM for MMP-8; 100 nM for MMP-9
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Sato, N., et al. 2003. J. Natl. Cancer Inst.95, 327.
Holleran, W.M., et al. 1997. Arch. Dermatol. Res. 289, 138.
Holleran, W.M., et al. 1997. Arch. Dermatol. Res. 289, 138.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
10-13 - German Storage Class 10 to 13
法规信息
新产品
此项目有