368620
Group III Caspase Inhibitor I
The Group III Caspase Inhibitor I controls the biological activity of Group III caspases (caspase-6, -8, -9, and -10). This small molecule/inhibitor is primarily used for Cancer applications.
别名:
Group III Caspase Inhibitor I, Z-AE(OMe)VD(OMe)-FMK
一般描述
A potent, cell-permeable, and irreversible inhibitor of Group III caspases (caspases-6, -8, -9, and -10), although more effective towards caspases -6 and -8. Also inhibits caspase-1 and caspase-3. When using with purified native or recombinant enzyme, pretreatment with an esterase is required.
生化/生理作用
Cell permeable: yes
Primary Target
caspase-1, caspase-3, caspase-6, caspase-8, caspase-9, caspase-10
caspase-1, caspase-3, caspase-6, caspase-8, caspase-9, caspase-10
Product does not compete with ATP.
Reversible: no
制备说明
Following reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
分析说明
Single spot by TLC
其他说明
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Z-Ala-Glu(OMe)-Val-Asp(OMe)-CH₂F*
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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