371725
GPR43 Agonist
>98% (HPLC), solid
别名:
GPR43（FFA2）激动剂, （S）-2-（4-氯苯基）-3，3-二甲基-N-（5-苯基噻唑-2-基）丁酰胺
产品名称
GPR43（FFA2）激动剂, The GPR43 (FFA2) Agonist controls the biological activity of GPR43. This small molecule/inhibitor is primarily used for Biochemicals applications.
质量水平
方案
>98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white
溶解性
DMSO: 50 mg/mL
运输
ambient
储存温度
2-8°C
一般描述
一种苯乙酰胺化合物，可作为FFA2的变构激动剂（GPR43），在hFFA2毛喉素诱导的cAMP分析中显示出相对于乙酸盐的左移乙酸盐剂量反应（IC50 = 0.7 µM）和111%的功效。
制备说明
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
其他说明
Wang, Y., et al. 2009.Bioorg.Med. Chem. Lett.20, 493.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
毒性：标准处理（A）
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Sandra M Holmberg et al.
Nature communications, 15(1), 3502-3502 (2024-04-26)
Beneficial gut bacteria are indispensable for developing colonic mucus and fully establishing its protective function against intestinal microorganisms. Low-fiber diet consumption alters the gut bacterial configuration and disturbs this microbe-mucus interaction, but the specific bacteria and microbial metabolites responsible for
Signe Schultz Pedersen et al.
The FEBS journal, 291(3), 566-583 (2023-11-21)
Butyrate, a gut microbial metabolite, has beneficial effects on glucose homeostasis and has become an attractive drug candidate for type 2 diabetes (T2D). Recently, we showed that butyrate protects pancreatic beta cells against cytokine-induced dysfunction. In this study, we explored
Anne Ørgaard et al.
Islets, 11(5), 103-111 (2019-08-31)
The intestinal microbiota has been demonstrated to influence host metabolism, and has been proposed to affect the development of obesity and type 2 diabetes (T2D), possibly through short-chain fatty acids (SCFAs) produced by fermentation of dietary fiber. There are some
Bandik Föh et al.
PloS one, 17(3), e0266071-e0266071 (2022-03-26)
The microbially-derived short-chain fatty acid butyrate is a central inhibitor of inflammatory innate and adaptive immune responses. Emerging evidence suggests that butyrate induces differentiation of IL-10-producing (IL-10+) regulatory B cells. However, the underlying mechanisms of butyrate-driven modulation of B cell
Mona Farhadipour et al.
iScience, 26(12), 108517-108517 (2023-12-21)
Stem cells are a keystone of intestinal homeostasis, but their function could be shifted during energy imbalance or by crosstalk with microbial metabolites in the stem cell niche. This study reports the effect of obesity and microbiota-derived short-chain fatty acids
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持