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371958

H-8, Dihydrochloride

Name: H-8, Dihydrochloride
Brand: MM

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of cyclic-nucleotide-dependent protein kinases.

别名:

H-8, Dihydrochloride, N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor I

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关于此项目

经验公式（希尔记法）:

C₁₂H₁₅N₃O₂S · 2HCl

化学文摘社编号:

113276-94-1

分子量:

338.25

UNSPSC Code:

12352200

MDL number:

MFCD00036962

Assay:

>95% (TLC)

Form:

lyophilized

Quality level:

100

Storage condition:

OK to freeze

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属性

Quality Level

100

assay

>95% (TLC)

form

lyophilized

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

solubility

water: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C12H15N3O2S.2ClH/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12;;/h2-6,9,13,15H,7-8H2,1H3;2*1H

InChI key

RJJLZYZEVNCZIW-UHFFFAOYSA-N

说明

General description

A potent, cell-permeable, reversible, and ATP-competitive, and highly active inhibitor of cyclic-nucleotide-dependent protein kinases. Inhibits myosin light chain kinase (K_i = 68 µM), protein kinase A (K_i = 1.2 µM), protein kinase C (K_i = 15 µM), and protein kinase G (K_i = 480 nM).

Biochem/physiol Actions

Cell permeable: yes

Product competes with ATP.

Reversible: yes

Target K_i: 68 µM against MLCK

Preparation Note

Further dilute with aqueous buffer just prior to use.

Other Notes

Ido, M., et al. 1991. Br. J. Cancer 64, 1103.
Hagiwara, M., et al. 1987. Mol. Pharmacol. 31, 523.
Inagaki, M., et al. 1986. Mol. Pharmacol.29, 577.
Hidaka, H., et al. 1984. Biochemistry23, 5036.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c