371958
H-8, Dihydrochloride
A potent, cell-permeable, reversible, and ATP-competitive inhibitor of cyclic-nucleotide-dependent protein kinases.
别名:
H-8, Dihydrochloride, N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor I
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C12H15N3O2S · 2HCl
化学文摘社编号:
分子量:
338.25
UNSPSC Code:
12352200
MDL number:
InChI
1S/C12H15N3O2S.2ClH/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12;;/h2-6,9,13,15H,7-8H2,1H3;2*1H
InChI key
RJJLZYZEVNCZIW-UHFFFAOYSA-N
assay
>95% (TLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
water: 10 mg/mL
shipped in
ambient
Quality Level
正在寻找类似产品? 访问 产品对比指南
General description
A potent, cell-permeable, reversible, and ATP-competitive, and highly active inhibitor of cyclic-nucleotide-dependent protein kinases. Inhibits myosin light chain kinase (Ki = 68 µM), protein kinase A (Ki = 1.2 µM), protein kinase C (Ki = 15 µM), and protein kinase G (Ki = 480 nM).
Biochem/physiol Actions
Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target Ki: 68 µM against MLCK
Preparation Note
Further dilute with aqueous buffer just prior to use.
Other Notes
Ido, M., et al. 1991. Br. J. Cancer 64, 1103.
Hagiwara, M., et al. 1987. Mol. Pharmacol. 31, 523.
Inagaki, M., et al. 1986. Mol. Pharmacol.29, 577.
Hidaka, H., et al. 1984. Biochemistry23, 5036.
Hagiwara, M., et al. 1987. Mol. Pharmacol. 31, 523.
Inagaki, M., et al. 1986. Mol. Pharmacol.29, 577.
Hidaka, H., et al. 1984. Biochemistry23, 5036.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持