A naturally occurring, cell-permeable diterpene with anti-inflammatory properties. Acts as a selective and direct inhibitor of IκB kinase (IC₅₀ = 24 µM) in TNF-α stimulated HeLa cells thereby prevents NF-κB activation. Also inhibits the production of nitric oxide in IL-1β or IL-17 stimulated normal human chondrocytes. Does not inhibit the activities of JNK and p38MAPK. Reported to be effective against murine blood and liver stages of malarial parasites. Inhibits VEGF-induced cell proliferation in vitro (IC₅₀ = 28.6 µM) and bFGF-induced angiogenesis in the chick chorioallantoic membrane (IC₅₀ = 10 µM).

Cell permeable: yes

Primary Target
IKB Kinase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 24 µM against IκB kinase

Packaged under inert gas

Toxicity: Harmful (C)

Following reconstitution aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 2 weeks at -20°C. Stock solutions in ethanol are stable for up to 2 months at -20°C.

Pulai, J.I., et al. 2005. J. Immunol.174, 5781.
Ojo-Amaize, E. A., et al. 2002. Cancer Res.62, 4007.
Ojo-Amaize, E.A., et al. 2001. Cell Immunol.209, 149.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany